Cape South Coast is a recently-designated South African wine region which forms part of the Western Cape Geographical Unit. It is located to the east of the Coastal Region in which the bulk of South African wine production takes place.

Because of its proximity to the ocean, cool climate grape varieties such as Pinot Noir, Chardonnay and Sauvignon Blanc are much more successful here than in most other parts of the country. Sparkling wine production is also seeing some growth.